Abstract
The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-β -lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 × MIC and 1 × MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35°C. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.
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Choi, J. Y., Soo Park, Y., Cho, C. H., Seon Park, Y., Shin, S. Y., Song, Y. G., … Kim, J. M. (2004). Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii. Clinical Microbiology and Infection, 10(12), 1098–1101. https://doi.org/10.1111/j.1469-0691.2004.00987.x
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