Effect of Karuk Leaves (Piper Sarmentosum Roxb) and White Galangal Rhizome (Alpinia Galanga L) Ethanol Extract on the Growth of Microsporum Gypseum and Candida Albicans in Vitro

Abstract

Piper sarmentosum Roxb are wild plants that are widely used as an itch and cough medicine. P. sarmentosum and Alpinia galanga contain flavonoid, saponin, and alkaloid which has a function as an antifungal. This study aims to determine the effect of extract ethanol of Karuk leaves and white galangal rhizome in influencing the growth of Microsporum gypseum in vitro. The study was carried out with an experimental method of fungi using the Kirby Bauer. The results showed that the ethanol extract of Karuk leaves (Piper sarmentosum ) and white galangal rhizome (Alpinia galanga) had an effective inhibitory effect on the growth of fungi M. gypseum and Candida albicans. The best inhibitory zone of Karuk leaf extract is at a concentration of 100% with a diameter of 34.2 mm inhibitory zone which is categorized as very strong (M. gypseum), diameter of 16.3 mm inhibitory zone which is categorized as strong (C. albicans) and while the inhibitory zone of galangal rhizome extract is the best, namely at a concentration of 100% with a diameter of 12,3 mm (C. albicans) and 32.06 mm (M. gypseum) inhibition with a very strong inhibitory response.