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Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

Cell Metabolism (2020) 31(2) 406-421.e7
DOI: 10.1016/j.cmet.2019.11.013
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Abstract

Genome-wide association studies have indicated that MerTK is a risk factor for liver fibrosis in NASH with an unknown mechanism. Cai et al. discovered that MerTK signaling in liver macrophages, which is enhanced in NASH owing to suppression of its cleavage by ADAM17, promotes TGF-β1 production, HSC activation, and liver fibrosis in NASH.

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Cai, B., Dongiovanni, P., Corey, K. E., Wang, X., Shmarakov, I. O., Zheng, Z., … Tabas, I. (2020). Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. Cell Metabolism, 31(2), 406-421.e7. https://doi.org/10.1016/j.cmet.2019.11.013

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