New catalytic model systems of tyrosinase: Fine tuning of the reactivity with pyrazole-based N-donor ligands

Abstract

Two new Cu(I) complexes have been synthesized and investigated as model systems of the enzyme tyrosinase. The corresponding ligands are based on a combination of an imine function with two different pyrazole groups. The reactivity of the prepared systems with respect to the conversion of monophenols to the corresponding ortho-quinones is investigated. The resulting data are compared to results obtained for other catalytic model systems of tyrosinase. © 2014 The Royal Society of Chemistry.