Journal Article

Oxetanes as promising modules in drug discovery

Angewandte Chemie - International Edition (2006) 45(46) 7736-7739
DOI: 10.1002/anie.200602343
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Abstract

(Chemical Equation Presented) Ring the changes: Introduction of an oxetane ring results in remarkably improved physico- and biochemical properties of the underlying scaffold. The oxetane ring confers enhanced solubility, reduces the metabolic degredation, lipophilicity, and amphiphilicity, and modulates the basicity of a nearby amine group. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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Wuitschik, G., Rogers-Evans, M., Müller, K., Fischer, H., Wagner, B., Schuler, F., … Carreira, E. M. (2006). Oxetanes as promising modules in drug discovery. Angewandte Chemie - International Edition, 45(46), 7736–7739. https://doi.org/10.1002/anie.200602343

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