Ahpatinins, new acid protease inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid

Abstract

A soil isolate, Streptomyces sp. WK-142, was found to produce new acid protease inhibitors, ahpatinins A, B, D, E, F and G active against pepsin and renin. Ahpatinin C was found to be identical with pepstatin A. The structure determinations were based on mass spectral data. Four of the compounds contain the unusual amino acid, 4-amino-3-hydroxy-5-phenylpentanoic acid as a building component. © 1986, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.