Synergistic effect in drug solubility by new binary micelles of poly(ϵ-caprolactone)-poly(ethylene oxide) and F127®

Abstract

Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127®) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.