Reversion towards benzimidazole susceptibility in Haemonchus contortus by resistance management strategies

Abstract

A study was aimed to observe the impact of withdrawal of anthelmintic type and increase in refugia through community dilution on reversion towards benzimidazole (BZ) susceptibility in Haemonchus contortus at an organized sheep farm in semi-arid Rajasthan. In sheep flocks of ICAR-Central Sheep and Wool Research Institute, Avikanagar reduced efficacy (80%) on faecal egg count reduction test (FECRT) with ED50 of 0.239 μg thiabendazole (TBZ)/ml on egg hatch assay (EHA) indicative of emergence of H. contortus resistant to BZ was observed in the year 1995. Following discontinuation of BZ for deworming at farm since 1996, the efficacy varied between 0–44% in the year 2000 with predominance of BZ-resistant alleles (>90%) between the year 2005 to 2010.