In vitro and in vivo evaluation of flavonoids from Heliotropium ellipticum exudate for antioxidant, antineoplastic and cytotoxic activities II

Abstract

Flavonoids are a large group of plant secondary metabolites that occur in various types of fruits and vegetable crops. The present study attempted to isolate and test flavonoids from the Heliotropium ellipticum exudate for antioxidant, antineoplastic and cytotoxic effects. Results obtained revealed that chrysin demonstrated higher DPPH scavenging (297.21±0.36%), reducing power (428.21±0.23%), superoxide anion scavenging (283.59±0.39%) and metal chelating (459.52±0.11%) activities. Chrysin showed greater antioxidant activity in comparison to the standard ascorbic acid. Similarly, it also exhibited high activity against sarcoma 180 (81.90%) and Chinese hamster V79 (37.2±0.67%) cells at different tested concentrations. Results obtained suggested that chrysin could be used as a potent antioxidant, antineoplastic and cytotoxic agent.