Β-Cyclodextrin mediated multicomponent synthesis of spiroindole derivatives in aqueous medium

Abstract

An efficient β-cyclodextrin catalyzed multicomponent synthetic protocol has been developed for the synthesis of spiro[indoline-3,2'quinazoline]-2,4'(3’H)-dione from isatoic anhydride, isatin and primary amine in aqueous medium. This methodology offers a convenient method for the synthesis of spiroindole quinazolines in excellent yields. To extend synthetic utility of protocol some dihydro quinazolines have been also synthesized.