Donor cyclopropanes in synthesis: Utilising silylmethylcyclopropanes to prepare 2,5-disubstituted tetrahydrofurans

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Abstract

The use of donor-only silylmethylcyclopropanes in the Lewis acid promoted reaction with aldehydes to generate 2,5-disubstituted tetrahydrofurans is described. The diastereoselectivity obtained in the product is very much dependent upon the temperature of the reaction. © 2011 Elsevier Ltd. All rights reserved.

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Dunn, J., Motevalli, M., & Dobbs, A. P. (2011). Donor cyclopropanes in synthesis: Utilising silylmethylcyclopropanes to prepare 2,5-disubstituted tetrahydrofurans. Tetrahedron Letters, 52(51), 6974–6977. https://doi.org/10.1016/j.tetlet.2011.10.091

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