Distribution of198Au and 133 Ba in Thoracic and Cervical Lymph Nodes of the Rat following the Intratracheal Instillation of 198 Au-colloid and 133BaS04

Abstract

Radioactive particles/P article size/Lymphatic dramage/Pulmonary region/Rat In this study, the transportability of ultrafine particles from the lung to the regional lymph nodes was investigated. 198Au-colloid particles with 0.02, um count median diameter (CMD) and particles with 0.39 jum CMD were instilled into rat lungs via intratracheal cannulas. Both the 193 Au-colloid and the l33BaS04 were distributed mainly to the posterior mediastinal lymph nodes. There were no significant differences between the quantities of the 198 Au-colloid and particles which reached the regional lymph nodes. This suggests that the mode of transporting ultrafine particles such as 198 Au-colloid from the lung to regional lymph nodes is similar to that of particles in the micrometer size range. © 1987, Journal of Radiation Research Editorial Committee. All rights reserved.