Alkyl, unsaturated, (hetero)aryl, and N-protected α-amino ketones by acylation of organometallic reagents

Abstract

Stable and easily accessible N-acylbenzotriazoles, derived from a variety of aliphatic, unsaturated, (hetero)aromatic, and N-protected α-amino carboxylic acids, were reacted with Grignard and heteroaryllithium reagents to afford corresponding ketones in good to excellent yields. © 2006 American Chemical Society.