Recyclable Palladium Catalyst Supported on Dolomite for Dynamic Kinetic Resolution of (±)-1-Phenylethylamine

Abstract

This work proposes a new selective palladium catalyst supported on dolomite to synthesize enantiomerically enriched N-[(R)-(+)-1-phenylethyl] amide. 2.5 wt.% Pd catalyst demonstrated high activity for reactions performed under mild conditions reaching a total enantiomeric excess up to 99%. It could be reused up to 5 cycles after the regeneration step. Graphical Abstract: [Figure not available: see fulltext.]