Chiral relay auxiliaries

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Abstract

An alternative strategy for chiral auxiliary design is described where configurationally flexible moieties are employed to relay, inert, and amplify the stereochemical information of existing stereogenic centres via chiral relay networks, thus ensuring efficient control of asymmetric induction.

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Bull, S. D., Davies, S. G., Fox, D. J., Garner, A. C., & Sellers, T. G. R. (1998). Chiral relay auxiliaries. Pure and Applied Chemistry, 70(8), 1501–1506. https://doi.org/10.1351/pac199870081501

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