Green methods for the synthesis of chalcones: An overview with appraisal to sustainable development and bioactive compounds

Abstract

In recent years, there has been a growing interest in developing green and sustainable synthetic strategies for chalcones, aiming to minimize waste, reduce the use of hazardous chemicals, and enhance the overall efficiency of the reactions. This review provides an overview of various green synthesis approaches for chalcones and their derivatives, emphasizing environmentally friendly techniques such as solvent-free reactions, microwave-assisted synthesis, ultrasound-assisted synthesis, and enzyme-catalytic methods. Additionally, the biological activities of chalcones synthesized via green methods are explored, underscoring their potential in drug development and therapeutic applications.