Three-component reactions of alkynone o-methyloximes, element selenium, and boronic acids leading to 4-organoselenylisoxazoles

Abstract

We report an Ag-catalyzed one-pot three-component reaction of alkynone o-methyloxime, element selenium, and boronic acid, providing a facile route to selenated isoxazole product. This protocol features high efficiency, wide substrate scope, and the use of selenium powder as the selenium source.