A small-molecule CD4-Mimetic compound protects bone marrow-liver-thymus humanized mice from HIV-1 Infection

Abstract

Background Small-molecule CD4-mimetic compounds (CD4mc) inhibit human immunodeficiency virus (HIV-1) entry by blocking binding to the CD4 receptor and by premature triggering of the viral envelope glycoprotein (Env) spike. Methods The efficacy of a CD4mc in protecting bone marrow-liver-thymus (BLT) humanized mice from vaginal HIV-1 challenge was evaluated. Results Intravaginal application of the CD4mc JP-III-48, either before or simultaneously with virus challenge, protected BLT humanized mice from HIV-1 JR-CSF infection in a dose- dependent manner. Conclusion The direct antiviral effects of a CD4mc prevent HIV-1 infection in a murine model of sexual transmission.