Effects of subarachnoid clonidine spinal anaesthesia with hyperbaric bupivacain

Abstract

This study was designed to determine the effects of clonidine addition to hyperbaric bupivacain 0.5% spinal analgesia for lower abdominal, perineal and lower limb surgery. A prospective observation was conducted on 40 ASA class I or II patients aged 20 - 70 years. The subjects were randomly allocated into two groups; each group consisted of 20 patients. Group I patients recieved 3 ml of hyperbaric bupivacain 0.5% plus 1 ml normal saline; group II patients recieved 3 ml of hyperbaric bupivacain 0.5% plus 1 ml clonidine (0.15 mg). Both group were compared concerning; time to onset of total motor block; characteristics of motor block using Bromage scale 0,1,2, and 3; characteristics of sensory block about the time to achieve maximum level of sensory block and the time for regression of sensory block to segment L2. Average analgesia level, the time to achieve motor blockade and sensory blockade in both groups showed no statistically significant difference. The duration of motor blockade Bromage scale 1,2 and 3 in both groups showed statiscally significant difference. Duration of motor blockade Bromage scale 1,2 and 3 was (288 ± 60), (215 ± 60) and (180 ± 50) min. in group II. Time for regression of sensory blockade of group II was (268 ± 70) min, that was also different significantly than group I. The changes of cardiovascular system concerning, systolic blood pressure, diastolic blood pressure and heart rate were no statistically significant difference in both groups. Side effects, sedation and dry mouth were found in several patients of group II.