The Implication of Organelle Cross Talk in AKI

Abstract

Organelle stress, such as mitochondrial or endoplasmic reticulum damage, plays a crucial role in the pathogenesis of acute kidney injury (AKI). Further, persistent organelle stress, which causes metabolic abnormality followed by inflammation and fibrosis, is an important mediator of AKI-to-CKD transition. Organelle stress closely links to the derangement of organelle cross talk. Organelles intricately interact with each other under the physiological conditions to maintain their function each other and subsequent cell fate. Organelle stress and their cross talk are now a focus of intensive researches in the field of AKI as they are in the field of CKD.