25-hydroxyvitamin d is associated with kidney function: The dong-gu study

Abstract

Although the kidneys play a leading part in the biosynthesis of vitamin D, there is no consensus regarding the relationship of the vitamin D concentration with kidney function. Thus, we aimed to estimate the correlation among 25-hydroxyvitamin D (25(OH)D), estimated glomerular filtration rate (eGFR), and albumin/creatinine ratio (ACR) in participants aged $50 y in Korea. This study consisted of 9,166 people who participated in a basic survey of the Dong-gu Study. Following an overnight fast, the blood and urine sample were assessed. The serum 25(OH)D, eGFR, ACR of each subject were measured. When adjusting for covariates and log-transformed ACR (Model III), the lower eGFR value was significantly associated with increasing 25(OH)D levels (,10.0: 71.5 [70.5–72.4]; 10.0–14.9: 70.0 [69.5–70.4]; 15.0–19.9: 68.7 [68.3–69.2]; $20.0: 67.4 [66.8–67.9] mL/min/1.73 m 2 , p,0.001). When adjusted for the same covariates and log-transformed eGFR (Model III), the lower ACR value was significantly associated with increasing 25(OH)D levels (,10.0: 57.4 [48.0–66.9]; 10.0–14.9: 40.8 [36.5–45.2]; 15.0–19.9: 34.0 [29.5–38.5]; $20.0: 34.3 [28.8–39.8] mg/mg creatinine, p,0.001). In conclusion, the mean values of eGFR were significantly decreased with increasing 25(OH)D levels independent of ACR. In addi-ton, the mean values of ACR were significantly decreased with increasing 25(OH)D levels independent of eGFR in participants aged $50 y in Korea.