Formulation of solid lipid nanoparticles and their applications

Abstract

Magnetite (Fe3O4) nanoparticles have been successfully synthesized by three methods viz chemical co- precipitation, oxidative hydrolysis and composite fluid methods. The phase structures, morphologies, chemical composition, and magnetic properties of Fe3O4 nanoparticles have been characterized by X-ray diffraction, scanning & transmission electron microscopy and vibrating sample magnetometer (VSM). The results indicate that that magnetite particles prepared by all the three methods showed crystalline nature and confirmed the presence of Fe3O4 (311 peak)as evident from XRD data, particles were spherical to elliptical in co-precipitation method and composite fluids method but were elongated crystalline in oxidative hydrolysis method from TEM and SEM images. All the particles showed excellent magnetic properties with saturation magnetization ranging from 39.5 to 41.5 emu/g which was evident from VSM data. This article gives the development of compatible lab scale methods for the synthesis of nano sized magnetite particles which are biocompatible and biodegradable and can be used as magnetic cores for magnetic carrier systems and help in targeting of pharmacologically active product in the body on application of external magnetic fields.