Cathelicidin LL37: Defense Roles in the Early Stages of Mycobacterium Tuberculosis Infection

Abstract

Mycobacterium tuberculosis (MTB) has developed into a very successful pathogen through a long history of co-evolution with humans, which can manipulate the body’s immune system for its persistent survival. The susceptibility of this disease depends to a large extent on the relationship between the host immune system and the virulence of MTB. Cathelicidin LL37 plays a vital role in innate immune response and can resist the invasion of MTB. This article focuses on the role of cathelicidin LL37 in against MTB infection in vivo.