Global dynamics and optimal control of a nonlinear fractional-order cholera model

Abstract

In this article, a fractional-order epidemic model for cholera is proposed and analyzed. Two transmission routes for cholera are considered to develop the compartmental epidemic model. The basic biological properties of the solutions of the fractional-order model are investigated. The global asymptotic stability of the equilibrium points have been established using appropriate Lyapunov functional. Moreover, a fractional-order control problem is presented, and its analytical solution is derived using Pontryagin’s maximum principle. Also, some graphical visualizations of the theoretical results are provided. It is found that the factional-order derivative only affect the time to reach the stationary states. Sensitivity analysis reveals that by reducing the rates of new recruitment and both the disease transmission rates, it may be possible to reduce the value of the basic reproduction number.