The Correlation of Values of Cd4 Count, Platelet, Pt, Aptt, Fibrinogen and Factor VIII Concentrations among HIV Positive Patients in FMC Owerri

Abstract

The correlation of values of CD4 Count, platelet, PT, APTT, fibrinogen and factor viii was carried out. One hundred and sixty four subjects were sampled, comprising one hundred and fourteen HIV positive subjects and fifty HIV negative subjects which served as the control. PT, APTT, Fibrinogen, Factor VIII, Platelet and CD4 count were analyzed using standard techniques. The results showed that HIV positive subjects had a significantly lower CD4 count (360.00±107.09) and Platelet count (157 ± 98.40) when compared with the HIV negative subjects (940 ± 220.05) and (228 ± 62.04) respectively. Also PT and APTT were significantly higher (P<0.05) in HIV positive subjects (19.56 ± 3.14) and (42.86 ± 7.10) respectively when compared with the HIV negative subjects (14.90 ± 1.91) and (37.90 ± 3.98) respectively. Whereas, there were no significant changes (P> 0.05) in fibrinogen and factor viii concentration between the HIV Positive subjects and the HIV negative subjects. Among the HIV positive subjects, platelet count did not differ significantly (p> 0.05) between those with CD4 count < 200 cells/µl and those with CD4 count ≥ 200 cells/ µl. However, PT and APTT showed significant changes (22.40 ± 2.96) and (48.20 ± 8.01) respectively, in HIV Positive subjects with CD4 count <200 cells/µl. Furthermore, there were positive correlation between PT and APTT, PT and CD4 count, APTT and CD4 count, Platelet and CD4 count (P<0.01) respectively while there were no correlation between other coagulation parameters tested(P > 0.01).