Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages

Abstract

Ménégaut et al. show that liver X receptor (LXR) agonists selectively increase IL1β mRNA levels independently of TLR activation. This effect, restricted to human macrophages, is mediated by an activation of hypoxia inducible factor (HIF) 1α through LXR. Accordingly, LXR agonists also potentiate other HIF-1α-dependent pathways, such as glycolysis.