Basic and clinical studies on CS-807 in the field of dermatology

Abstract

1) MICs (106CFU/ml) of R-3763, CEX and CFT were determined against 51 strains of Staphylococcus aureus isolated from the lesions of skin infections. MICs of R-3763 were more than 3.13μg/ml for all strains and more than 100μg/ml for 26 strains, whereas MICs of CEX were more than 1.56μg/ml for all strains and more than 100μg/ml for 24 strains, and MICs of CFT were 0.78-50μg/ml for all strains. 2) Serum and skin levels of R-3763 after venous injection (20mg/kg) were determined in rats at 30 min. Serum levels were 16.4±0.7μg/ml, and the corresponding skin levels were 9.0±0.6μg/g (wet skin)(n=5). 3) CS-807 was used clinically in 21 cases of skin infections and the following results were obtained: excellent 5, good 8, fair 7 and poor 1. As to side-effects and abnormal laboratory findings, loose stool was observed in one case, as were elevated eosinophils in two, S-GPT in one. S-K in one, and LDH in one. © 1988, Japanese Society of Chemotherapy. All rights reserved.