The physiopathological effects of quercetin on oxidative stress in radiation of 4.5 g mobile phone exposed liver tissue of rat

Abstract

OBJECTIVE: The study was aimed to evaluate the physiopathological consideration of the effects of electromagnetic field (EMF) from the radiation of 4.5 G mobile phones on the liver tissue of rats and quercetin (Qu) applied as an antioxidant for reducing these effects. METHODS: Male Wistar-Albino rats were divided into four groups with 8 rats in each group. Group 1 (control group), Group 2 (sham group), Group 3 (EMF group) and Group 4 (EMF + Qu). From the animals sacrificed at the end of the 30th day; liver tissues were taken for histopathological and immunohistochemical examinations. RESULTS: In the liver tissue of the electromagnetic field group; dilatation of sinusitis was determined to be higher than in the sham group. It was concluded that the concentration of caspase-3 and TNF-α immunopositive cells was in the EMF group (+3) level and also the immunostaining was stronger, it caused an increase in malondialdehyde level, the difference between the groups was statistically significant, in terms of superoxide dismutase, catalase activities, the difference was not significant. CONCLUSION: It was determined that 2600 MHz EMF exposure caused damage to the liver, 100 mg/kg/day quercetin was not sufficient to prevent this damage.