Drug-eluting nanofibrous wound dressings composed of polycaprolactone and gelatin augment diabetic wounds healing via reducing oxidative stress and inflammation: An in vitro and in vivo study

Abstract

Diabetes is a prevalent medical condition that often leads to complications, including diabetic wounds that can have serious consequences such as infections, amputations, and death. In the current research, lodoxamide was loaded into electrospun polycaprolacton/gelatin scaffolds In order to improve wound healing in a rat model. Our developed dressings were characterized in vitro using various methods and then applied on a rat model of excisional wound. Study showed that the dressings were not toxic and promoted migration potential of skin-derived fibroblast cells. Wound healing study showed that lodoxamide-loaded dressings had markedly higher healing potential than other scaffolds and augmented collagen deposition and epithelialization. Gene expression studies showed that TNF-α, glutathione peroxidase, and superoxide dismutase genes were significantly downregulated by lodoxamide-loaded scaffolds.