Design and formulation of piroxicam tablets

Abstract

Piroxicam is a potent nonsteroidal anti-inflammatory drug (NSAID) with a long half-life that permits once daily dose. It exerts a better toleration than other NSAID's with a relatively low incidence of adverse effects. In this study many trials were made to formulate piroxicam as plain tablets with properties comparable to those of capsules and in agreement with pharmacopoeial standards. Different formulas were prepared by the application of direct compression method and wet granulation method with the addition of different excipients. The wet granulation method used in the preparation of piroxicam tablets was modified to improve the properties of the produced tablets. The characteristics of the prepared formulas were tested and the results showed that formula D prepared by wet granulation method, containing PVP as binder and lactose as diluent is the most appropriate formula with a rapid disintegration time and complete dissolution as that of piroxicam capsules. Accordingly, formula D was chosen to be a promising formula of piroxicam plain tablet that could be manufactured as a mass product. ‫اﻟﺨﻼﺻﺔ‬ ‫اﻟﺒﺎﻳﺮوآﺴ‬ ‫ﺮﺮ‬ ‫ﻳﻌﺘﺒﺮ‬ ‫ﻴﻜ‬ ‫ﻣﺠﻤﻮﻋ‬ ‫ﻦﻦ‬ ‫ﻣﻦ‬ ‫ﺎم‬ ‫ﺪﺪ‬ ‫اﻷﻣﺪ‬ ‫ﻞﻞ‬ ‫ﻃﻮﻳﻞ‬ ‫ﻮﻮل‬ ‫ﻣﻔﻌﻮ‬ ‫وذو‬ ‫ﺎﺎل‬ ‫ﻓﻌﺎ‬ ‫دواء‬ ‫ﻮﻮ‬ ‫وهﻮ‬ ‫ﺎﺎت‬ ‫ﻟﻼﻟﺘﻬﺎﺑﺎ‬ ‫ﺎﺎدة‬ ‫اﻟﻤﻀﺎ‬ ‫ﺘﺘﺮودﻳﻪ‬ ‫اﻟﺴﺘ‬ ‫ﺮﺮ‬ ‫ﻏﻴﺮ‬ ‫ﺔﺔ‬ ‫اﻷدوﻳﺔ‬ ‫ﻪ‬ ‫ﺪﺪ‬ ‫واﺣﺪ‬ ‫ﺔﺔ‬ ‫ﺑﺠﺮﻋﺔ‬ ‫ﻲﻲ‬ ‫وﻳﻌﻄﻲ‬ ‫ة‬ ‫ﺄﺄﺛﻴﺮات‬ ‫اﻟﺘﺄ‬ ‫ﻦﻦ‬ ‫ﻣﻦ‬ ‫ﻞﻞ‬ ‫ﻗﻠﻴﻞ‬ ‫ﻊﻊ‬ ‫ﻣﻊ‬ ‫ﻲﻲ‬ ‫اﻟﻌﻼﺟﻲ‬ ‫ﺄﺄﺛﻴﺮﻩ‬ ‫ﺗﺄ‬ ‫ﺮﺮ‬ ‫ﻳﻈﻬﺮ‬ ‫و‬ ‫ﺎﺎ‬ ‫ﻳﻮﻣﻴﺎ‬ ‫اﻟ‬ ‫ﺔﺔ‬ ‫ﺠﺎﻧﺒﻴﺔ‬. ‫ﺪﺪﻩ‬ ‫ﻋﺪ‬ ‫ﺮﺮاء‬ ‫أﺟﺮ‬ ‫ﻢﻢ‬ ‫ﺗﻢ‬ ‫ﺔﺔ‬ ‫اﻟﺪراﺳﺔ‬ ‫ﺬﺬﻩ‬ ‫هﺬ‬ ‫ﻲﻲ‬ ‫ﻓﻲ‬ ‫ﻣﻤﺎﺛﻠ‬ ‫ﻔﻔﺎت‬ ‫ﺻﻔ‬ ‫ﺎﺎ‬ ‫ﻟﻬﺎ‬ ‫ﺮﺮاص‬ ‫أﻗﺮ‬ ‫ﻜﻜﻞ‬ ‫ﺑﺸﻜ‬ ‫ﺪﺪواء‬ ‫اﻟﺪ‬ ‫ﺬﺬا‬ ‫هﺬ‬ ‫ﻴﻴﻴﻎ‬ ‫ﻟﺘﺼﻴ‬ ‫ﺎﺎوﻻت‬ ‫ﻣﺤﺎ‬ ‫ﺔ‬ ‫ﻮﻮل‬ ‫ﺑﺎﻟﻜﺒﺴﻮ‬ ‫ﺔﺔ‬ ‫اﻟﺨﺎﺻﺔ‬ ‫ﻚﻚ‬ ‫ﻟﺘﻠﻚ‬ ‫ﺔﺔ‬ ‫اﻷدوﻳﺔ‬ ‫ﺎﺎﺗﻴﺮ‬ ‫ﻟﺪﺳﺎ‬ ‫ﺔﺔ‬ ‫ﻣﻄﺎﺑﻘﺔ‬ ‫و‬ ، ‫ﺪﺪ‬ ‫وﻗﺪ‬ ‫ﻋﺪد‬ ‫ﺣﻀﺮت‬ ‫ﻃﺮﻳﻘ‬ ‫ﺑﺎﺳﺘﺨﺪام‬ ‫اﻟﺼﻴﻎ‬ ‫ﻣﻦ‬ ‫ﺔ‬ ‫وﻃﺮﻳﻘ‬ ‫اﻟﻤﺒﺎﺷﺮ‬ ‫اﻟﻀﻐﻂ‬ ‫ﺔ‬ ‫اﻟﺘﺤﺒ‬ ‫ﻴ‬ ‫اﻟﺮﻃﺐﺐ‬ ‫ﺐ‬ ‫ﻣﻊﻊ‬ ‫وﻣﺨﺘﻠﻔﺔﺔ‬ ‫ﻣﺘﻌﺪﺪدة‬ ‫ﻣﻀﺎﺎﻓﺎت‬ ، ‫ﺗﻢﻢ‬ ‫آﻤﺎﺎ‬ ‫ﻃﺮﻳﻘ‬ ‫ﻋﻠﻰ‬ ‫اﻟﺘﻌﺪﻳﻼت‬ ‫ﺑﻌﺾ‬ ‫أﺟﺮاء‬ ‫ﺔ‬ ‫هﻲ‬ ‫آﺎﻧﺖ‬ ‫اﻟﺘﻲ‬ ‫اﻟﺮﻃﺐ‬ ‫اﻟﺘﺤﺒﻴﺐ‬ ‫اﻟﻄﺮﻳﻘﺔ‬ ‫اﻟﻤﺴﺘﺤﻀﺮ‬ ‫هﺬا‬ ‫ﺗﺼﻨﻴﻊ‬ ‫ﻓﻲ‬ ‫اﻟﻤﺨﺘﺎرة‬. ‫وﺑﺪراﺳﺔﺔ‬ ‫أﻧ‬ ‫اﻟﺘﻲ‬ ‫اﻟﺤﺒﻮب‬ ‫ﺻﻔﺎت‬ ‫اﻟﺼﻴﻴﻐﺔ‬ ‫أن‬ ‫إﻟﻰﻰ‬ ‫اﻟﻨﺘﺎﺎﺋﺞ‬ ‫أﺷﺎﺎرت‬ ‫اﻟﻤﺨﺘﻠﻔﺔ‬ ‫ﻟﻠﺼﻴﻎ‬ ‫ﺘﺠﺖ‬) D () ‫اﻟﺮﻃﺐﺐ‬ ‫اﻟﺘﺤﺒﻴﺐﺐ‬ ‫ﺑﻄﺮﻳﻔﺔﺔ‬ ‫اﻟﻤﺤﻀﺮﺮة‬ (‫واﻟﺘﻲ‬ ‫اﺣﺘﻮت‬ ‫اﻟﺒﻮﻟﻲ‬ ‫ﻣﺎدﻩ‬ ‫ﻋﻠﻰ‬ ‫ﭬ‬ ‫ﺑﺎﻳﺮوﻟﻴﺪﻳﻦ‬ ‫ﻨﻴﻞ‬) PVP (‫اﻟﻼآﺘﻮز‬ ‫وﺳﻜﺮ‬ ‫راﺑﻄﻪ‬ ‫آﻤﺎدﻩ‬) Lactose (‫آﻤﺎد‬ ‫ة‬ ‫ﻣﺨﻔﻔ‬ ‫ﺔ‬ ‫ﻟ‬ ‫ﻬ‬ ‫ﺎ‬ ‫وﻗﺖﺖ‬ ‫ﻣﻤﺎﺛﻠ‬ ‫آﺎﻣﻠﺔ‬ ‫وإذاﺑﺔ‬ ‫ﺳﺮﻳﻊ‬ ‫ﺗﻔﺘﺖ‬ ‫ﺔ‬ ‫ﺑﺎﻟﻜﺒﺴﻮل‬ ‫اﻟﺨﺎﺻﺔ‬ ‫ﻟﺘﻠﻚ‬ ‫و‬ ‫اﻟﺼﻴﻐﺔ‬ ‫هﻲ‬ ‫اﻟﻤﺴﺘﺤﻀﺮﺮ‬ ‫ﻟﻬﺬا‬ ‫اﻟﻤﺜﺎﻟﻴﺔ‬. ‫اﺧﺘﻴﺮﺮت‬ ‫ﻟﺬﺬﻟﻚ‬ ‫هﺬﺬﻩ‬ ‫اﻟﺼﻴﻴﻐﺔ‬ ‫ﻟ‬ ‫أﻗﺮاص‬ ‫ﺑﺸﻜﻞ‬ ‫اﻟﺪواء‬ ‫هﺬا‬ ‫ﺘﺤﻀﻴﺮ‬. ‫وﻋﻠﻴﻪ‬ ‫اﻟﺘﺮآﻴﺒﺔ‬ ‫ﺑﺎن‬ ‫اﻻﺳﺘﻨﺘﺎج‬ ‫ﻳﻤﻜﻦ‬) D (‫ﺗﺴﺘﺘﺨﺪم‬ ‫أن‬ ‫اﻟﻤﻤﻜﻦﻦ‬ ‫وﻣﻦﻦ‬ ‫اﻟﻮاﻋﺪﺪة‬ ‫اﻟﺼﻴﻴﻐﺔ‬ ‫هﻲ‬ ‫ﻣﻤﺎﺛﻠ‬ ‫أﻗﺮاص‬ ‫وﺑﺸﻜﻞ‬ ‫اﻟﺪواء‬ ‫هﺬا‬ ‫إﻧﺘﺎج‬ ‫ﻓﻲ‬ ‫ﺔ‬ ‫اﻟﺸﺮآﺔ‬ ‫ﻧﻔﺲ‬ ‫ﻗﺒﻞ‬ ‫ﻣﻦ‬ ‫اﻟﻤﻨﺘﺞ‬ ‫اﻟﻜﺒﺴﻮل‬ ‫ﻟﻤﺴﺘﺤﻀﺮ‬ .