Pharmacokinetic of Oral Drug Absorptionusing Modified Compartmental Absorption and Transit Modelin Small Intestine

Abstract

The compartment analysis and transit (CAT) model to predict oral drug absorption is presented by Yu and co-author. The transit equation in the small intestine of the CAT modelis linear equation. In this research, the transit equationin the small intestine of our presentmodel is nonlinear equation. Therefore, we included nonlinear factor in transit equation of small intestine seven compartment. To modify the small intestine equation, the first and fourth to seventh compartment equations are made nonlinear, while the second and third compartments are two times from initial model. The prediction of plasma drug concentrationwas adjusted with secondary data so that the parameters used were the time of gastric emptying and the microscopic rate constant for each dose of drug that is atenolol. The accuracy deterministic coefficient (R 2 ) results will were used to compare between our presentmodel and the CAT model. The equation is made nonlinear as it is close to the gastric organs so the calculated amount of mass is absorbed in the small intestinal.The results of deterministic coefficients to atenolol for dose masses 25, 50 and 100 mg were above 90% for this present model.The R 2 value of between experimental and the modified CAT modeltime courses are above 90% indicates the modified CAT modelresults are good agreement.