Clinical Significance of Serum Bone Gla Protein and Urinary.Γ—Gla as Biochemical Markers in Primary Hyperparathyroidism

Abstract

The serum bone Gla-protein (BGP) and urinary Γ-carboxyglutamic acid (Γ-Gla) levels were determined in patients with primary hyperparathyroidism (PHP). The mean serum BGP and urinary Γ-Gla levels were 18.6±2.34 ng/ml and 65.5±4.62nmoles/mgCr, respectively, for the 11 patients with the skeletal type of PHP, 5.13±0.85ng/ml and 45.2±1.33nmoles/mgCr for the 4 with the chemical type, and 7.91±2.43ng/ml and 43.2±3.47nmoles/mgCr for the 5 with the renal type. Thus, patients with skeletal-type PHP had significantly higher serum BGP and urinary Γ-Gla levels than those with the other type of PHP. Serum BGP levels had significant positive correlations with serum Ca (r=0.64, P<0.005), serum Al-p (r=0.77, P<0.001) and serum PTH (r=0.45, P<0.005). Urinary Γ-Gla levels also had significant positive correlations with serum Ca(r=0.50, P<0.05), serum Al-p (r=0.67, P<0.005), serum 1,25(OH)2D (r=0.62, P<0.02), and serum BGP (r=0.72, P<0.001). Mineral content in the left radius had significant negative correlations with serum BGP levels (r=-0.73, P<0.001) and urinary Γ-Gla levels (r=-0.59, P<0.01). As these data show, serum BGP and urinary Γ-Gla levels clearly reflect the abnormal bone metabolism and can therefore be useful biochemical markers in PHP. © 1986, The Japan Endocrine Society. All rights reserved.