Antibiotics from basidiomycetes. Ix) Oudemansin, an antifungal antibiotic from oudemansiella mucida (schrader Ex Fr.) hoehnel (agaricales)

Abstract

From mycelial cultures of Oudemansiella mucida a crystalline optically active antibiotic, oudemansin (2), has been isolated; its structure is closely related to strobilurin A (1). The relative configuration of oudemansin have been determined by X-ray analysis. The antibiotic exhibits strong antifungal properties and inhibits respiration in fungi, cells of the ascitic form of Ehrlich carcinoma, and rat liver mitochondria. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.