High Mortality and Complications in Patients Admitted With Takotsubo Cardiomyopathy With More Than Double Mortality in Men Without Improvement in Outcome Over the Years

Abstract

BACKGROUND: Takotsubo cardiomyopathy continues to be a major cause of mortality and morbidity. The goal of this study was to evaluate the outcome data of patients with Takotsubo cardiomyopathy using a large inpatient database. METHODS AND RESULTS: We used the Nationwide Inpatient Sample database for our study. We evaluated trends, mortality, and complications of patients admitted with Takotsubo cardiomyopathy from available years 2016 to 2020 in adults >18. A total of 199 890 patients with Takotsubo were found in our database with 83% being female and higher prevalence with age, White race, and highest income. Mortality was high at 6.5% with no significant improvement over the years studied. Furthermore, major complications were substantial. Cardiogenic shock occurred in 6.6%, atrial fibrillation in 20.7%, cardiac arrest in 3.4%, congestive heart failure in 35.9%, and stroke in 5.3%. Mortality was more than double in men in comparison to women (11.2% versus 5.5%). CONCLUSIONS: Takotsubo cardiomyopathy is associated with high mortality and complications with no improvement in outcome over the 5-year study with higher mortality in men. Further improvement in care is needed to improve outcomes.