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Microevolution of Mycobacterium tuberculosis in a tuberculosis patient

Journal of Clinical Microbiology (2010) 48(10) 3813-3816
DOI: 10.1128/JCM.00556-10
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Abstract

Five Mycobacterium tuberculosis isolates were obtained from three body sites from a Dutch patient. The isolates displayed a single genotype by 24-locus MIRU-VNTR typing (except for a single locus not amplified from one isolate) but were differentiated by small variations in IS6110 fingerprints, spoligotypes, 6 hypervariable MIRU-VNTR loci, and/or DiversiLab profiles, revealing patterns of microevolution in a clonal infection. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

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Al-Hajoj, S. A. M., Akkerman, O., Parwati, I., Al-Gamdi, S., Rahim, Z., Van Soolingen, D., … Van Der Zanden, A. G. M. (2010). Microevolution of Mycobacterium tuberculosis in a tuberculosis patient. Journal of Clinical Microbiology, 48(10), 3813–3816. https://doi.org/10.1128/JCM.00556-10

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