Dactinomycin in NPM1 -Mutated Acute Myeloid Leukemia

  • Falini B
  • Brunetti L
  • Martelli M
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Abstract

Dactinomycin is an old drug with activity in some childhood cancers; it acts as an inhibitor of RNA polymerase I. Its activity in acute myeloid leukemia has not been thoroughly examined. However, it has induced remissions in some patients with treatment-refractory disease.

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Falini, B., Brunetti, L., & Martelli, M. P. (2015). Dactinomycin in NPM1 -Mutated Acute Myeloid Leukemia. New England Journal of Medicine, 373(12), 1180–1182. https://doi.org/10.1056/nejmc1509584

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