Selected Pharmacological Applications of 1 st Row Transition Metal Complexes: A review

Abstract

Ninety elements occur naturally on earth. Out of these, nine are radioactive and among the remaining eighty one that could support life, sixty one are metals. Our bodies have approximately 3% metal. Researchers have been established that some of metal complexes were biologically active. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. Investigations in this area focus mostly on the speciation of metal species in biological media based on possible interactions of these metal ions with diverse biomolecules. In an effort to contribute to future development of new therapeutics or diagnostic agents metallo pharmaceuticals used as anticancer agents, anti-HIV, metal-mediated antibiotics, antibacterials, antivirals, antiparasitics, antiarthritics, antidiabetics and radio-sensitizing agents appear in therapeutic medicinal inorganic chemistry. The medicinal uses and applications of metals and metal complexes are of increasing clinical and commercial importance.