Abstract
Novel pyrimidine nucleosides with fluorocyclopentene ring were synthesized from D-ribose via stereoselective Grignard reaction and electrophilic vinyl fluorination as key steps. Among compounds tested, cytosine derivative 15a was found to show high growth inhibition against a broad range of human tumor cell lines.
Cite
CITATION STYLE
APA
Zhao, L. X., Yun, M., Kim, H. O., Lee, J. A., Choi, W. J., Lee, K. M., … Jeong, L. S. (2005). Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines. Nucleic Acids Symposium Series (2004), (49), 107–108. https://doi.org/10.1093/nass/49.1.107
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
Already have an account? Sign in
Sign up for free