Transcriptional inhibition by DNA torsional stress

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Abstract

Most genome transactions are favored by DNA (-) torsional stress, i.e. unconstrained unwinding or supercoiling of DNA. A question raised here is whether DNA (+) torsional stress, which precludes DNA unwinding, could be also relevant in gene regulation. Such DNA twist dynamics could be determined by chromatin architecture.

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Roca, J. (2011). Transcriptional inhibition by DNA torsional stress. Transcription, 2(2), 82–85. https://doi.org/10.4161/trns.2.2.14807

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