Treatment of uveitis with pyrimethamine (Daraprim)

Abstract

A controlled clinical trial of Daraprim (pyrimethamine) in cases of active uveitis showed: (1) Daraprim had no detectable effect on the improvement of cases with a negative toxoplasma reaction. (2) Daraprim exerted a statistically significant effect on the improvement of cases having a positive toxoplasma reaction. (3) Toxoplasmosis was probably the cause of some 25 per cent. of the cases having a positive toxoplasmosis reaction. (4) The best response was obtained in cases of circumscribed choroido-retinitis.