EXAMINING THE ROLE OF THE NITRIC OXID SYSTEM AS THE ESSENTIAL PATHOGENETIC LINK IN STEVENS-JOHNSON SYNDROME

Abstract

OBJECTIVE: The aim: To determine a possible role of nitric oxide system as one of the pathogenesis links in Stevens-Johnson syndrome depending on the severity of disease progression. PATIENTS AND METHODS: Material and methods: We examined 11 patients with Stevens-Johnson syndrome. The function of nitric oxide system (NO - NOS) in blood serum was examined. RESULTS: Results: During the study of nitric oxide system (NO-NOS) in patients with SJS, it was observed that NO2¯ level was increased by 1.53 times, NO3¯ level - by 3.33 times, activity of total NOS - by 5.78 times, constitutive (cNOS) - by 1.81 times and inducible (iNOS) - by 13.36 times. CONCLUSION: Conclusions: The intensity of nitric oxide system function was studied in patients with Stevens-Johnson syndrome and dependence of changes of its parameters from the clinical signs of disease was detected. It was found that the determination of nitrite and nitrate anion levels in blood serum can be used for the purpose of predicting the disease course and choosing the therapy methods for the patients with SJS.