Background: Periodic fever syndromes are caused by deregulation of Interleukin-1β release. Results: Defective autophagy leads to accumulation of damaged mitochondria in monocytes. Conclusion: Mitochondrial components in the cytosol cause priming of monocytes for Interleukin-1β release. Significance: The molecular mechanism behind deregulated cytokine secretion provides new clues for intervention. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Van Der Burgh, R., Nijhuis, L., Pervolaraki, K., Compeer, E. B., Jongeneel, L. H., Van Gijn, M., … Boes, M. (2014). Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion. Journal of Biological Chemistry, 289(8), 5000–5012. https://doi.org/10.1074/jbc.M113.536920