A concentric circle model of multivesicular body cargo sorting

81Citations
Citations of this article
114Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Targeting of ubiquitylated transmembrane proteins into luminal vesicles of endosomal multivesicular bodies (MVBs) depends on their recognition by endosomal sorting complexes required for transport (ESCRTs), which are also required for MVB vesicle formation. The model originally proposed for how ESCRTs function succinctly summarizes much of the protein-protein interaction and genetic data but oversimplifies the coordination of cargo recognition and cannot explain why ESCRTs are required for the budding of MVB vesicles. Recent structural and functional studies of ESCRT complexes suggest an alternative model that might direct the next series of breakthroughs in understanding protein sorting through the MVB pathway.

Cite

CITATION STYLE

APA

Nickerson, D. P., Russell, M. R. G., & Odorizzi, G. (2007). A concentric circle model of multivesicular body cargo sorting. EMBO Reports, 8(7), 644–650. https://doi.org/10.1038/sj.embor.7401004

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free