Magnetic resonance water proton relaxation in protein solutions and tissue: T1ρ dispersion characterization

20Citations
Citations of this article
64Readers
Mendeley users who have this article in their library.

Abstract

Background: Image contrast in clinical MRI is often determined by differences in tissue water proton relaxation behavior. However, many aspects of water proton relaxation in complex biological media, such as protein solutions and tissue are not well understood, perhaps due to the limited empirical data. Principal Findings: Water proton T1, T2, and T 1ρ of protein solutions and tissue were measured systematically under multiple conditions. Crosslinking or aggregation of protein decreased T2 and T1ρ, but did not change high-field T 1. T1ρ dispersion profiles were similar for crosslinked protein solutions, myocardial tissue, and cartilage, and exhibited power law behavior with T1ρ(0) values that closely approximated T2. The T1ρ dispersion of mobile protein solutions was flat above 5 kHz, but showed a steep curve below 5 kHz that was sensitive to changes in pH. The T1ρ dispersion of crosslinked BSA and cartilage in DMSO solvent closely resembled that of water solvent above 5 kHz but showed decreased dispersion below 5 kHz. Conclusions: Proton exchange is a minor pathway for tissue T1 and T1ρ relaxation above 5 kHz. Potential models for relaxation are discussed, however the same molecular mechanism appears to be responsible across 5 decades of frequencies from T 1ρ to T1. © 2010 Chen, Kim.

References Powered by Scopus

Relaxation effects in nuclear magnetic resonance absorption

4764Citations
N/AReaders
Get full text

Primary structure effects on peptide group hydrogen exchange

1838Citations
N/AReaders
Get full text

A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1–100 MHz: Dependence on tissue type, NMR frequency, temperature, species, excision, and age

1052Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Controversies in cardiovascular MR imaging: T2-weighted imaging should not be used to delineate the area at risk in ischemic myocardial injury

81Citations
N/AReaders
Get full text

Effects of formalin fixation and temperature on MR relaxation times in the human brain

80Citations
N/AReaders
Get full text

T2-weighted imaging to assess post-infarct myocardium at risk

64Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Chen, E. L., & Kim, R. J. (2010). Magnetic resonance water proton relaxation in protein solutions and tissue: T1ρ dispersion characterization. PLoS ONE, 5(1). https://doi.org/10.1371/journal.pone.0008565

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 23

46%

Researcher 21

42%

Professor / Associate Prof. 5

10%

Lecturer / Post doc 1

2%

Readers' Discipline

Tooltip

Physics and Astronomy 16

42%

Chemistry 9

24%

Medicine and Dentistry 8

21%

Engineering 5

13%

Save time finding and organizing research with Mendeley

Sign up for free