Cinnamomum cassia metanolik ekstraktı ilave edilen diş macunlarının in vitro incelenmesi

Abstract

Objective: In recent years, it has developed resistance to antibiotics and antibacterial chemicals used in the treatment of a large number of bacterial diseases. For this reason, today, an alternative product has been searched for instead of synthetic chemicals. Phytochemicals in traditional medicine and isolated from plants are seen as a good alternative to synthetic chemicals. The purpose of this study; to investigate the antibacterial activity of toothpastes of different contents and toothpastes with Cinnamomum cassia methanolic extract added against Staphylococcus aureus bacteria. Methods: In the study, the experimental set up of six different toothpastes, a positive control group of a flüoride free toothpaste and a distilled water negative control group. The content of C. cassia methanolic extract was determined by GC/MS. Anti-S. aureus activities of toothpastes alone and with C. cassia methanol extract were determined according to the agar disc diffusion method and n = 3 repeats. Inhibition zone diameters were determined using digital calipers and all results were evaluated statistically. Results: According to the GC/MS, cinnamaldehyde, one of the main substances of C. cassia methanolic extract was found to be higher than other components. The most effective toothpaste was found different after adding C. cassia methanol extract and the most effective toothpaste after adding C. cassia methanol extract (p <0.05). Conclusion: With this study, it has been shown that toothpaste with low or no anti-S. aureus effect can be enriched with herbal extracts to increase their biological activities. Studies that evaluate the effectiveness of toothpaste-methanolic extract combinations proved by us to have antibacterial efficacy, such as remineralization, whitening, desensitization, which constitute oral and dental health, should also be evaluated. In further studies, it has been determined that various studies can be performed to use the essential oils used in the study in place of various antimicrobials in the content of toothpastes.