An Overview on Surface Modified Dendrimers: Current Direction and Future Perspectives

Abstract

Dendrimers are made up of synthetic and nano-sized molecules which represent a tree-like three-dimensional (3D) structure that delivers surface versatility and functionality. This review revealed that the surface modified agents like acetylation, polyphenols, and conjugation might be a promising nano-platform for more targeted site diagnosis, unique structural activity and higher bioavailability compatibility. Polyamidoamine (PAMAM) dendrimers are multipurpose nanocarriers, which can easily load with drugs and be amended by target-specific ligands, which are very specific to the receptor. PAMAM dendrimers are best suited for the release of hydrophobic drugs, as they can be encapsulated inside the internal void of PAMAM dendrimers. Moreover, current trends and future strategies, surface modification of dimensional globular nano-polymeric that are best for drug delivery are described with their potential applications in the biomedical sector. The aim of the present review article is to study the different methods of synthesis of dendrimers, how they can be modified with different methods as per the requirement, types of dendrimers and their use in different sectors.