Synthesis and biological activity of some novel pyrazolines

Abstract

Chalcones were prepared from substituted acetophenones and substituted benzaldehydes and condensed with hydrazine hydrate in ethanol to get the corresponding pyrazolines (Pdc1 to Pdc 14). The compounds were synthesized and characterizes by TLC, melting points, IR, and 1H-NMR spectra. All the synthesized compounds were screened for their antibacterial and anti-inflammatory activities. The in vitro antibacterial activity was checked against two Gram positive microorganisms (S. aureus and B. subtilis) and two Gram negative microorganisms (E. coli and P. aureginosa). Some of tested compounds exhibited promising antibacterial and anti-inflammatory activities.