Shedding of infectious borna disease virus-1 in living bicolored white-toothed shrews

60Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.

Abstract

Background: Many RNA viruses arise from animal reservoirs, namely bats, rodents and insectivores but mechanisms of virus maintenance and transmission still need to be addressed. The bicolored white-toothed shrew (Crocidura leucodon) has recently been identified as reservoir of the neurotropic Borna disease virus 1 (BoDV-1). Principal Findings: Six out of eleven wild living bicoloured white-toothed shrews were trapped and revealed to be naturally infected with BoDV-1. All shrews were monitored in captivity in a long-term study over a time period up to 600 days that differed between the individual shrews. Interestingly, all six animals showed an asymptomatic course of infection despite virus shedding via various routes indicating a highly adapted host-pathogen interaction. Infectious virus and viral RNA were demonstrated in saliva, urine, skin swabs, lacrimal fluid and faeces, both during the first 8 weeks of the investigation period and for long time shedding after more than 250 days in captivity. Conclusions: The various ways of shedding ensure successful virus maintenance in the reservoir population but also transmission to accidental hosts such as horses and sheep. Naturally BoDV-1-infected living shrews serve as excellent tool to unravel host and pathogen factors responsible for persistent viral co-existence in reservoir species while maintaining their physiological integrity despite high viral load in many organ systems.

References Powered by Scopus

Global trends in emerging infectious diseases

5742Citations
N/AReaders
Get full text

Sea view version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building

4728Citations
N/AReaders
Get full text

Bats: Important reservoir hosts of emerging viruses

1168Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Neurotropic virus infections as the cause of immediate and delayed neuropathology

230Citations
N/AReaders
Get full text

Fatal encephalitic borna disease virus 1 in solid-organ transplant recipients: To the editor

102Citations
N/AReaders
Get full text

Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999–2019: an epidemiological investigation

88Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Nobach, D., Bourg, M., Herzog, S., Lange-Herbst, H., Encarnação, J. A., Eickmann, M., … Kuhn, J. H. (2015). Shedding of infectious borna disease virus-1 in living bicolored white-toothed shrews. PLoS ONE, 10(8). https://doi.org/10.1371/journal.pone.0137018

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 9

53%

Researcher 4

24%

Professor / Associate Prof. 2

12%

Lecturer / Post doc 2

12%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 6

33%

Medicine and Dentistry 6

33%

Veterinary Science and Veterinary Medic... 5

28%

Neuroscience 1

6%

Article Metrics

Tooltip
Mentions
References: 1

Save time finding and organizing research with Mendeley

Sign up for free