Multicomponent [3+2] cycloaddition strategy: Stereoselective synthesis of novel polycyclic cage-like systems and dispiro compounds

Abstract

The syntheses of novel structurally intriguing hexacyclic cage-like compounds have been achieved from the three-component tandem [3+2] cycloaddition-intramolecular annulation reactions of ninhydrin, α-amino acids and (E)-3-arylidene-1-methylpiperidin-4-ones. On the other hand the four-component reactions of ninhydrin, o-phenylenediamine, α-amino acids and (E)-3-arylidene-1-methylpiperidin-4-ones afforded novel polycyclic dispiro compounds.