Randomised clinical trial of intravitreal Avastin vs photodynamic therapy and intravitreal triamcinolone: Long-term results

Abstract

PurposeTo compare 1-year functional and anatomic outcomes of intravitreal bevacizumab (IVB) and photodynamic therapy plus intravitreal triamcinolone (PDT+IVTA) combination in patients with neovascular age-related macular degeneration (AMD).MethodsIn this prospective, randomised, controlled clinical trial, 28 patients were included. All patients were randomised 1: 1 to 0.04 ml/1 mg of IVB or PDT plus same day 0.1 ml/4 mg IVTA (PDT+IVTA). Follow-up examinations were performed in monthly intervals in IVB group and every 3 months in PDTIVTA group. Main outcomes were change in mean visual acuity (VA), mean central retinal thickness (CRT) and the mean number of treatments.ResultsAt month 12, mean VA improved to a 1.5-line gain in IVB group, and lost three letters in PDTIVTA group (P = 0.02). Mean CRT was reduced from 357 m at baseline to 244 m at month 12 in IVB group and from 326 μm to 254 μm, respectively, in PDT+IVTA group (P = 0.8). The mean number of treatments was 6.8 in the IVB group vs1.9 in the PDT+IVTA group. No significant local or systemic safety concerns were detected during follow-up time.ConclusionsPatients treated with IVB showed a significant better VA outcome compared with the PDTIVTA group despite the fact that both modalities showed equal potency in reducing CRT during a 12-month period. © 2009 Macmillan Publishers Limited All rights reserved.